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    The body’s endocannabinoid system is composed of two types of receptors, referred to as CB1 and CB2. The interaction of these receptors with their agonists and antagonists helps to support the body’s natural response to stress, anxiety, normal pain signaling, bone metabolism and more. Ultimately, the optimal functioning of the endocannabinoid leads to the maintenance of overall health and wellbeing. One such naturally occurring cannabinoid, known as cannabidiol, can be found in the hemp plant. SJR provides a unique water soluble, cannabidiol-rich hemp extract powder, in a patented water soluble delivery system for optimal absorption. While the full biological roles of cannabidiol (CBD) are still being elucidated, research has demonstrated a strong impact on the endocannabinoid system through an indirect interaction with the CB2 receptor. CBD appears to have little to no interaction with CB1 receptors.


    Vitamin D3 
    Although vitamin D3 is generally associated with bone health, research has clearly demonstrated that the health effects of vitamin D3 extend far beyond the musculoskeletal system. Large portions of the population have been shown to have insufficient levels of vitamin D, and these suboptimal levels of vitamin D3 may be linked the body’s ability to generate a normal pain response as well as with normal muscle function. Vitamin D’s emerging role in the body’s neuromuscular system may be significant, and supplementing with appropriate amounts of vitamin D can help play a role in supporting optimal health.


    Berberine is an alkaloid found in many plants including goldenseal, phellodendron, and various species within the genus Berberis. Native to central and southern Europe as well as Africa and Asia, plants containing berberine has been used by many cultures around the world for a wide variety of therapeutic effects. While berberine is often associated with its beneficial impact on both blood glucose and blood lipids, recent data has implicated berberine as playing a role in the body’s perception of and response to pain. Data have revealed that berberine posses significant antinociceptive and anti-inflammatory effects, which may in part be mediated via opioid receptors. In combination with the other ingredients in XXXX, berberine can help to play an important and synergist role in one’s overall well-being.


    Resveratrol is a polyphenol found in grapes, peanuts as well as certain berries. Although research has suggested many health promoting properties of resveratrol, the mechanisms by which resveratrol may exerts its effects have not been well understood. One mechanism may involve the interaction of resveratrol with 5- hydroxytryptamine type 3A receptors. 5-HT receptors are ligand-gated ion channels that are involved in synaptic transmission and play a role in the regulation of pain sensitivity. Interestingly, resveratrol has been shown to enhance 5-hydroxytryptamine type 3A receptor-mediated ion currents. Additionally, resveratrol has been shown to inhibit glycine receptor mediated ion currents. Both of these actions at the level of cellular receptors reveal new clues to the potential mechanisms that underlie resveratrol’s health-promoting effects.


    Hyaluronic acid
    Hyaluronic acid is a mucopolysaccharide comprised of repeating units of D-glucuronic acid and N-acetyl glucosamine that plays an important role in joint and connective tissue structure. Hyaluronic acid is also a significant component of synovial fluid and has the ability to bind water and helps to lubricate and cushion joints. As with other molecules in the body, hyaluronic acid tends to decrease with age. Oral supplementation with hyaluronic acid has been shown to support the health of knee joints and can work in concert with the other ingredients contained in XXXX to support overall healthy aging. The hyaluronic acid used in this formulation is low in molecular weight and is not animal- derived.